Treatment comparison.
Efficacy (Abbott %) · Powdery mildew, bunch severity · US grape 2025Higher is better
VIRTUOSA® · control comparable to the grower program. Untreated bunch severity: 53%.
VIRTUOSA®BIOLOGICAL CROP PROTECTION
A patented, multisite biological fungicide for gray mold (Botrytis), powdery mildew and white mold (Sclerotinia) in high-value crops.
DEVELOPED AND MANUFACTURED BY APHEA.BIOUp to21 days
of pre-harvest interval on synthetic fungicides. Late-season disease arrives when growers can no longer spray.Pre-harvest intervals of synthetic fungicides: 1 to 21 days
Three diseases.
Less fruit
to harvest.
Gray mold (Botrytis), powdery mildew and white mold (Sclerotinia) damage grapes, berries and vegetables, reducing fruit quality and marketable yield.
VIRTUOSA®.
A field-tested solution for fungal diseases.
One product controls gray mold (Botrytis), powdery mildew and white mold (Sclerotinia) through multiple modes of action. Built for IPM programs.
Spray right up to harvest.
0-day PHI* and 4-hour REI* keep protection running right up to harvest, with no MRL restrictions* for export and premium markets.
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FIELD PERFORMANCE01 / EVIDENCE EXPLORER
Field performance.
In a program approach, VIRTUOSA® delivers control of grape powdery mildew and Botrytis bunch rot comparable to standard chemical programs.
Grape trials at a glance.
Efficacy (Abbott %) · Higher is betterAphea.Bio US field trials 2025
| Disease | Grower program | VIRTUOSA® | Biological reference |
|---|---|---|---|
| Powdery mildew (bunch severity) | 93% | 87% (32 fl oz, 7-day) · 84% (14-day) | 81% |
| Botrytis bunch rot (bunch incidence) | 51% | 45% (32 fl oz) · 54% (64 fl oz) | 45% |
| Untreated disease level | 53% severity (powdery mildew) · 52% (Botrytis) · 4 of 5 US trials valid | ||
C / FIELD EVALUATION PROGRAMAphea.Bio field trial program · 2023–2025
PRODUCT DOCUMENTATION
Download product data sheetProduct data sheets for grape and strawberry. Technical dossier, label and SDS follow at registration.
TECHNOLOGY & MANUFACTURING02 / APEXbio™
From discovery
to formulated product.
VIRTUOSA® comes from APEXbio™, Aphea.Bio’s R&D platform, and is formulated as a liquid suspension concentrate. Developed and manufactured by Aphea.Bio.
Explore the APEXbio™ platformPRODUCT FORMATSVIRTUOSA®
VIRTUOSA®
packaging.
VIRTUOSA® AG for outdoor crops in 2.5 gal (9.5 L).
VIRTUOSA® GH for greenhouse in 1 qt (950 mL).
| Net volume | 1 qt (950 mL) |
|---|---|
| Units / case | 10 |
| Segment | Greenhouse |
| Net volume | 2.5 gal (9.5 L) |
|---|---|
| Units / case | 2 |
| Segment | Outdoor crops |
Two commercial labels: VIRTUOSA® AG for outdoor crops and VIRTUOSA® GH for greenhouse. Pack illustrations are placeholders for the final artwork.
SPRAY PROGRAM
Where VIRTUOSA® fits in a grape season.
Move through the season to see when VIRTUOSA® replaces a chemical spray, and why it matters at each stage.
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VIRTUOSA®Chemical fungicide
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VIRTUOSA® ADVANTAGES · HIGHLIGHTED FOR THIS STAGE
Two key diseases, one productResistance managementGentle on flowers*Up to harvest, no MRLs*Liquid, easy to use
Illustrative grape spray program; timing follows the product label. *Pending EPA registration.
CROPS & DISEASES
One product. Six crops.
DISEASES COVERED
Botrytis bunch rot · Powdery mildew
WHERE IT FITS
32–64 fl oz/A. Powdery mildew: begin before disease onset, repeat every 7 to 14 days. Botrytis: apply at bloom, bunch closure, veraison and before harvest.
DISEASES COVERED
Gray mold · Powdery mildew
WHERE IT FITS
In a program with standard fungicides, on a 5 to 7-day interval, starting preventively.
DISEASES COVERED
Gray mold
WHERE IT FITS
Blueberries, raspberries and blackberries: late-season control close to harvest.
DISEASES COVERED
Powdery mildew · Gray mold
WHERE IT FITS
For field and greenhouse, crop-safe in heat.
DISEASES COVERED
Powdery mildew · White mold
WHERE IT FITS
For cucumbers, melons and squash.
DISEASES COVERED
White mold · Gray mold
WHERE IT FITS
For lettuce and other leafy vegetables.
Crops and diseases follow the planned US label. Pending EPA registration.
WHY VIRTUOSA®
Multisite protection. Biological flexibility.
01
Disease control without compromise.
On a 14-day rotation, control comparable to the full conventional program in key crop and disease combinations. 245 trials in the US and Europe, 2023–2025.
02
All-season flexibility.
0-day PHI* and 4-hour REI* let growers spray right up to harvest, including in warm conditions where sulfur becomes risky.
03
No MRL issues.
No MRL restrictions* and no residue documentation required. Built for export and premium domestic channels.
04
Multiple modes of action.
Secondary metabolites, competitive exclusion and myco-parasitism in one patented strain. Reduces resistance selection pressure.
05
Designed for IPM.
Safe on beneficial insects, no phytotoxicity, compatible with sulfur, copper and common tank-mix partners.
*Subject to EPA registration and the approved label.
WHERE TO GET IT
Look for VIRTUOSA® technology.
UNITED STATES
VIRTUOSA®
EPA registration pending. Local partner announced at launch.
CANADA
In registration
EUROPEAN UNION
In registration
with VIRTUOSA® technology
by aphea.bio ✳︎
by aphea.bio ✳︎
ALSO SOLD UNDER PARTNER BRANDS
In some markets VIRTUOSA® reaches growers under a partner’s brand. Look for this mark on the pack or leaflet: it means the product is built on VIRTUOSA® technology from Aphea.Bio. Partner products will be listed here by country.
Not sure? Check the active ingredient line on the label: Streptomyces griseofuscus strain M1A1.
VIRTUOSA® specs.
| Registered trademark | VIRTUOSA® |
|---|---|
| Category | Biological fungicide (foliar) · FRAC group BM02 |
| Origin | APEXbio™ discovery platform |
| Biological basis | Streptomyces griseofuscus strain M1A1, patent-protected |
| Crops | Grapes, berries, cucurbits, tomatoes and fruiting vegetables, leafy greens |
| Target | Gray mold (Botrytis), powdery mildew, white mold (Sclerotinia) |
| Pack formats | VIRTUOSA® AG 2.5 gal · VIRTUOSA® GH 1 qt Liquid suspension concentrate, low use rate |
| US milestone | EPA registration pending EPA dossier submitted May 2024 · Aphea.Bio US launch planned for 2027, subject to approval |
VIRTUOSA® is a patented, multisite biological fungicide for consistent control of powdery mildew, gray mold (Botrytis) and white mold (Sclerotinia) in grapes, berries, cucurbits, tomatoes and leafy greens.*
Source: VIRTUOSA® launch materialsBuilt for IPM programs. On a 14-day rotation with synthetics, it delivers control comparable to the full conventional program in key crop and disease combinations. It is compatible with sulfur, copper and common tank-mix partners, and safe on beneficial insects.
Source: VIRTUOSA® launch materials245 field trials across 6 crops in the US and Europe over 2023–2025, with development ongoing. In US grape trials in 2025, programs with VIRTUOSA® were comparable to the standard chemical program.
Source: VIRTUOSA® launch materialsThree complementary modes of action in one patented strain: secondary metabolites with activity against fungal pathogens, competitive exclusion, and myco-parasitism, where lytic enzymes break down pathogen cell walls. This reduces resistance selection pressure across the program.
Source: VIRTUOSA® launch materialsThe EPA dossier was submitted in May 2024 and registration is pending. VIRTUOSA® is not yet approved for sale or use. State registrations follow federal approval. 0-day PHI, 4-hour REI and no MRL restrictions are subject to the approved label.
Source: VIRTUOSA® launch materialsDistribution of the finished product manufactured by Aphea.Bio, under the VIRTUOSA® brand or a partner brand. For early-stage pipeline assets: research and development partnerships.
Discuss a partnershipaphea.bio
INVESTMENT & COMMERCIAL DEVELOPMENTInvestment &
commercial partnerships.
Distribute VIRTUOSA in your market, develop pipeline assets together, or discuss investment in Aphea.Bio.
Find a VIRTUOSA® reseller.
FIND A RESELLER
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Planned timing, subject to registration in each country. Distributors are listed here as they are announced.
VIRTUOSA®
distribution.
Aphea.Bio manufactures the liquid product. Regional partners provide local branding, logistics and sales, with the VIRTUOSA® technology mark linking the brands.
Research & development
partnerships.
Partners advance early-stage leads through development, registration and commercialisation. The Bayer collaboration targets biological control of sap-sucking insects.